Integrative Cardiovascular Laboratories

Microcirculatory Core Laboratory: Director's Page

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Fruzsina K. Johnson, MD

Professor of Preclinical Sciences

Hungarian born, Dr. Johnson started Medical School at Semmelweis University (Budapest, Hungary) in 1991 and began her research carrear with their 2nd Department of Physiology. During her medical training, Dr. Johnson participated in a two year Research Associate Externship at New York Medical College's Department of Pharmacology. Following the completion of her MD, Dr. Johnson joined Tulane’s Department of Physiology as a Postdoctoral Fellow in 2000, rose to the rank of Instructor in 2002 and became an Assistant Professor in 2004. In June of 2006, Dr. Johnson was recruited to the Trauma and Emergency Medicine Division of the Department of Surgery at the University of Texas Health Science Center at San Antonio.Dr. Johnson most recently relocated to William Carey University College of Osteopathic Medicine.

Dr. Johnson’s major research interests include cardiovascular function, microcirculation and vascular pathophysiology during hemorrhagic shock, obesity and hypertension. Her research focuses on biological roles for arginase, L-arginine and nitric oxide, as well as porphyrin metabolism and carbon monoxide. Her early work demonstrated the importance of endogenously-formed carbon monoxide as a messenger within the vasculature. In subsequent studies, Dr. Johnson has provided compelling evidence that endogenously-formed carbon monoxide not only promotes relaxation of vascular smooth muscle, but can promote vasoconstriction by interfering with the vasodilatory actions of the nitric oxide system. Her research has profound implications as it suggests that endogeously-formed carbon monoxide may contribute to endothelial dysfunction and promote vasospasticity in certain hypertensive models and pathological conditions. Her recent studies showed that increased arginase expression promotes endothelial dysfunction during salt-induced hypertension.

Dr. Johnson is a former recipient of an American Heart Postdoctoral Fellowship awarded though the Regional American Heart-Southeast Affiliate, and has recieved one year of equipment/supplies support from Solvay Pharmaceuticals Hypertension Yearly Grants Award Program. She was a Junior Faculty Investigator on the Tulane Center of Biomedical Research Excellence grant from NIH. Fruzsina Johnson is also a recipient of the Microcirculatory Society's distinguished August Krogh Award. In addition, she has received a Carolyn Tum Suden/Francis A. Hellebrant Professional Opportunity Award from the American Physiological Society and the Tulane's Dean of the School of Medicine Award at Tulane Research Day in 2000. Dr. Johnson is a member of the American Physiological Society, the Microcirculatory Society, the American Heart Association’s Council for High Blood Pressure Research, the American Diabetes Association and the Shock Society.

Complete Curriculum Vitae

E-mail: fjohnson


Location and Contact Information

The Microcirculatory Core is now located at William Carey University in Hattiesburg MS

For further information contact:
Fruzsina K. Johnson, MD
Professor of Preclinical Sciences
College of Osteopathic Medicine
William Carey University
498 Tuscan Avenue
Hattiesburg, MS 39401
Ph: (601) 318-6073
Fax: (601) 318-6032
E-mail: fjohnson


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