1: Curr Opin Neurol. 2000 Dec;13(6):709-13. The effects of carbon monoxide as a neurotransmitter. Johnson RA, Johnson FK. Department of Physiology, Tulane School of Medicine, New Orleans, Louisiana 70112, USA. robertj393@aol.com Neural tissues generate carbon monoxide. Although neuronal carbon monoxide does not appear to be released in a directed manner, heme-derived carbon monoxide affects neuronally mediated activities. This rather suggests that endogenously formed carbon monoxide is an important neuromodulator. In addition, it appears that carbon monoxide may contribute to various neuropathological conditions. Publication Types: Review Review, Tutorial PMID: 11148674 [PubMed - indexed for MEDLINE]