The Microcirculatory Core Laboratory's primary mission is to study regulation of cardiovascular resistance at the vascular level. Our experties contribute to the mission of the Consortium for Integrative Cardiovascular Research by providing a intermediate level of investigation between integrative (intact animal and whole organ) and vascular biology (isolated endothelial and vascular smooth muscle cell) studies.
The Microcirculatory Core Laboratory specialises in isolated vascular preparations to study intrinsic regulation of vascular tone. We are interested in endothelial and smooth muscle cell function in health and disease. We predominantly study resistance vessels (arterioles and small arteries), since these are primary determinants of resistance in the cardiovascular circuit. We use disease models where resistance vascular function is altered, such as experimental models of hemorrhagic shock, hypertension, obesity, insulin resistance, and diabetes.